Structure of PDB 3puk Chain A Binding Site BS01

Receptor Information
>3puk Chain A (length=552) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERGLKSVVWRKIKTAVFDDCRKEGEWKIMLLDEFTTKLLSSCCKMTDLLE
EGITVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKKYKAA
YIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPQESQVYTLDVPDAF
YYCYSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASK
LAQLVEKKLEDYYKIDEKGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQA
MAYDLLPIENDTYKYKTDGKEKEAVLEEDDDLWVRVRHRHIAVVLEEIPK
LMKEISSTKSLSALTQLMKKMPHFRKQISKQVVHLNLAEDCMNKFKLNIE
KLCKTEQDLALGTDAEGQRVKDSMLVLLPVLLNKNHDNCDKIRAVLLYIF
GINGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPLRKDR
SAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYRTNYLELDRKNGSRLI
IFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTHILTPRKLLDDIKMLNKS
KD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3puk Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation
Resolution3.054 Å
Binding residue
(original residue number in PDB)		F113 C114 F119 K123 I130 R132 C133 E135 I221 E223
Binding residue
(residue number reindexed from 1)		F107 C108 F113 K117 I124 R126 C127 E129 I215 E217
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0006887 exocytosis
GO:0007420 brain development
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0022615 protein to membrane docking
GO:0030073 insulin secretion
GO:0032868 response to insulin
GO:0043312 neutrophil degranulation
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046325 negative regulation of D-glucose import
GO:0070527 platelet aggregation
GO:0071346 cellular response to type II interferon
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031091 platelet alpha granule
GO:0042581 specific granule
GO:0045335 phagocytic vesicle
GO:0070820 tertiary granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3puk, PDBe:3puk, PDBj:3puk
PDBsum3puk
PubMed21193638
UniProtQ60770|STXB3_MOUSE Syntaxin-binding protein 3 (Gene Name=Stxbp3)

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