Structure of PDB 3ptg Chain A Binding Site BS01

Receptor Information
>3ptg Chain A (length=340) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGLAVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR
HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLT
FPKLFPDSLFPAHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV
WYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ptg Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		M159 R165 Y168 K198 S199 D200 C201 W362 E367
Binding residue
(residue number reindexed from 1)		M114 R120 Y123 K153 S154 D155 C156 W301 E306
Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162 T168
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3ptg, PDBe:3ptg, PDBj:3ptg
PDBsum3ptg
PubMed21316234
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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