Structure of PDB 3pta Chain A Binding Site BS01

Receptor Information
>3pta Chain A (length=904) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAM
KEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSY
YKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHW
FCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAME
GGMDPGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQ
KEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSS
PKEPVDEDLYPEHYRKYSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIK
IRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYG
EDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGKLPKLRTL
DVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCN
ILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSK
FKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGY
QCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLS
VVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEP
QSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNI
EVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVACDPAARQFNTLI
PWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHR
VVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCM
LAKA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pta Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K649 R650 R652 K683 Q684 A685 N1233
Binding residue
(residue number reindexed from 1)		K3 R4 R6 K37 Q38 A39 N541
Enzymatic activity
Catalytic site (original residue number in PDB) C1226 E1266 R1310 R1312
Catalytic site (residue number reindexed from 1) C534 E574 R618 R620
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:3pta, PDBe:3pta, PDBj:3pta
PDBsum3pta
PubMed21163962
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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