Structure of PDB 3pp5 Chain A Binding Site BS01

Receptor Information
>3pp5 Chain A (length=63) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKTNIQKDWEQREFIEDMSINIQKIVEFLNKFELSTRNKLSDLNEKLTIL
DRQVDYLEATFKT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3pp5 Chain A Residue 71 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3pp5 High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		E15 E18
Binding residue
(residue number reindexed from 1)		E13 E16
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0000281 mitotic cytokinesis
GO:0007015 actin filament organization
GO:0008064 regulation of actin polymerization or depolymerization
GO:0031269 pseudopodium assembly
GO:0046847 filopodium assembly
GO:0048870 cell motility
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005911 cell-cell junction
GO:0031143 pseudopodium
GO:0031209 SCAR complex
GO:0031252 cell leading edge
GO:0032433 filopodium tip
GO:0060187 cell pole

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3pp5, PDBe:3pp5, PDBj:3pp5
PDBsum3pp5
PubMed21701600
UniProtQ54X65|BRK1_DICDI Protein BRICK1 (Gene Name=brk1)

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