Structure of PDB 3pov Chain A Binding Site BS01

Receptor Information
>3pov Chain A (length=445) Species: 435895 (Human herpesvirus 8 type M) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPTPADLFSEDYLVDTLDGLTVDDQQAVLASLSFSKFLKHAKVRDWCAQA
KIQPSMPALRMAYNYFLFSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASV
YAACSQMNAHQRHHICCLVERATSSQSLNPVWDALRDGIISSSKFHWAVK
QQKIFSPAFGLRCEEVVKTLLATLLHPDETNCLDYGFMQSPQNGIFGVSL
DFAANVKTFDPNCKVYEIKCRFKYTFAKMECDPIYAAYQRLYEAPGKLAL
KDFFYSISKPAVEYVGLGKLPSESDYLVAYDQEWEACPRKKRKLTPLHNL
IRECILHNSTTESDVYVLTDPQDTRGQISIKARFKANLFVNVRHSYFYQV
LLQSSIVEEYIGSPKYYIATGFFRKRGYQDPVNCTIGGDALDPHVEIPTL
LIVTPVYFPRGAKHRLLHQAANFWSRSAKDTFPYIKWDFSYLSAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pov Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R248 F249 K250 Y373
Binding residue
(residue number reindexed from 1)		R221 F222 K223 Y346
Binding affinityPDBbind-CN: Kd=6uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3pov, PDBe:3pov, PDBj:3pov
PDBsum3pov
PubMed21421561
UniProtP88925

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