Structure of PDB 3pmn Chain A Binding Site BS01

Receptor Information
>3pmn Chain A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQE
ACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKT
AQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQT
VQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLL
DSLRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACAL
LYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVPGRVLPTPTEKDVFRLL
GLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3pmn Replication infidelity via a mismatch with Watson-Crick geometry.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		W274 V462 K463 G464 E470 R514 R517 K521 L527 H530
Binding residue
(residue number reindexed from 1)		W26 V214 K215 G216 E217 R261 R264 K268 L274 H277
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D179 D181 D237
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3pmn, PDBe:3pmn, PDBj:3pmn
PDBsum3pmn
PubMed21233421
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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