Structure of PDB 3plz Chain A Binding Site BS01

Receptor Information
>3plz Chain A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEKLSTFGLMCKMADQTLFSIV
EWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVT
GQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLF
SLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIR
AISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3plz Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2).
Resolution1.75 Å
Binding residue
(original residue number in PDB)		F354 V357 R361 M375 Q379
Binding residue
(residue number reindexed from 1)		F47 V50 R54 M68 Q72
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:3plz, PDBe:3plz, PDBj:3plz
PDBsum3plz
PubMed21391689
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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