Structure of PDB 3pls Chain A Binding Site BS01

Receptor Information

>3pls Chain A (length=298) Species: 9606 (Homo sapiens)

RDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRI
QCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHV
LLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDL
AARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESL
QTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQP
EYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3pls Chain A Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3pls The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis
• Resolution: 2.24 Å
• Binding residue (original residue number in PDB): N1213 D1226
• Binding residue (residue number reindexed from 1): N154 D167
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D1208 A1210 R1212 N1213 D1226 D1235
• Catalytic site (residue number reindexed from 1): D149 A151 R153 N154 D167 D176
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:3pls, PDBe:3pls, PDBj:3pls
• PDBsum: 3pls
• PubMed: 20726546
• UniProt: Q04912|RON_HUMAN Macrophage-stimulating protein receptor (Gene Name=MST1R)