Structure of PDB 3pfv Chain A Binding Site BS01

Receptor Information
>3pfv Chain A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYD
DNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNL
TKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVP
WKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPW
GSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLG
QWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTG
LA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pfv Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
Resolution2.27 Å
Binding residue
(original residue number in PDB)		S70 P71 Y266 R286 C289 T290 R291 Y299 Q308 T309 I310 K314 E326 F328 Y329
Binding residue
(residue number reindexed from 1)		S27 P28 Y223 R243 C246 T247 R248 Y256 Q265 T266 I267 K271 E283 F285 Y286
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005509 calcium ion binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0023051 regulation of signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:3pfv, PDBe:3pfv, PDBj:3pfv
PDBsum3pfv
PubMed
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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