Structure of PDB 3p1g Chain A Binding Site BS01

Receptor Information
>3p1g Chain A (length=157) Species: 438045 (Xenotropic MuLV-related virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AETHGTRPDLTDQPIPDADYTWYTDGSSFLQEGQRRAGAAVTTETEVIWA
RALPAGTSAQRAELIALTQALKMAEGKKLNVYTDSRYAFATAHVHSEGRE
IKNKNEILALLKALFLPKRLSIIHCPGHQKGNSAEARGNRMADQAAREAA
MKAVLET
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3p1g Chain A Residue 163 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3p1g Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		D524 E562 D583
Binding residue
(residue number reindexed from 1)		D25 E63 D84
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3p1g, PDBe:3p1g, PDBj:3p1g
PDBsum3p1g
PubMed22252812
UniProtA1Z651|POL_XMRV6 Gag-Pol polyprotein (Gene Name=gag-pol)

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