Structure of PDB 3oyj Chain A Binding Site BS01
Receptor Information
>3oyj Chain A (length=368) Species:
11963
(Human spumaretrovirus) [
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LDAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKI
VLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNK
ASGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYP
TKAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLE
FSTPYHPQSQGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTY
SPVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPST
PPASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDH
LGNNRTVSIDNLKPTSHQ
Ligand information
>3oyj Chain C (length=19) [
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attgtcatggaatttcgca
Receptor-Ligand Complex Structure
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PDB
3oyj
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Resolution
2.68 Å
Binding residue
(original residue number in PDB)
I112 L113 R114 P115 E207 F208 T210 Q215 S216 G218 K219 R222 R229 S258 N348 R350 T351
Binding residue
(residue number reindexed from 1)
I105 L106 R107 P108 E200 F201 T203 Q208 S209 G211 K212 R215 R222 S251 N341 R343 T344
Enzymatic activity
Enzyme Commision number
2.7.7.-
2.7.7.49
: RNA-directed DNA polymerase.
2.7.7.7
: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4
: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
Biological Process
GO:0015074
DNA integration
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Molecular Function
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Biological Process
External links
PDB
RCSB:3oyj
,
PDBe:3oyj
,
PDBj:3oyj
PDBsum
3oyj
PubMed
21030679
UniProt
P14350
|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)
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