Structure of PDB 3oxi Chain A Binding Site BS01

Receptor Information
>3oxi Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL
SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLV
MELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI
VVKSDCTLKILDFGVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK
ILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFP
KLFPDSLFPHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYD
PAEVREHTIEEWKELIYKEVMN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3oxi Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		M159 R165 Y168 S199 D200 C201 W362
Binding residue
(residue number reindexed from 1)		M114 R120 Y123 S154 D155 C156 W298
Enzymatic activity
Catalytic site (original residue number in PDB) D189 K191 N194 D207 T226
Catalytic site (residue number reindexed from 1) D144 K146 N149 D162 T166
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3oxi, PDBe:3oxi, PDBj:3oxi
PDBsum3oxi
PubMed21071223
UniProtP53779|MK10_HUMAN Mitogen-activated protein kinase 10 (Gene Name=MAPK10)

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