Structure of PDB 3ouw Chain A Binding Site BS01

Receptor Information

>3ouw Chain A (length=496) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTN
DVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAI
TTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY
GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPA
IVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLV
QLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD
REDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPL
IKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQREGVRMEE
IVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVL
CELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSE

Ligand information

>3ouw Chain B (length=28) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GDPELCATDEMIPFKLADIKSSLVNESE

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3ouw Biochemical and structural characterization of beta-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1.
Resolution	2.91 Å
Binding residue (original residue number in PDB)	K180 H219 F253 Y254 H260 K292 I296 K335 R386 D390 N426 C429 N430 K435 R474 R515 Y654
Binding residue (residue number reindexed from 1)	K24 H63 F97 Y98 H104 K136 I140 K179 R230 D234 N270 C273 N274 K279 R318 R359 Y486

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0045296	cadherin binding

	Biological Process
GO:0007155	cell adhesion

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3ouw, PDBe:3ouw, PDBj:3ouw
PDBsum	3ouw
PubMed	21075118
UniProt	Q02248\|CTNB1_MOUSE Catenin beta-1 (Gene Name=Ctnnb1)

[Back to BioLiP]