Structure of PDB 3otz Chain A Binding Site BS01

Receptor Information

>3otz Chain A (length=205) Species: 2210 (Methanosarcina thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SNIRENPVTPANPEPSAPVIDPTAYIDPQASVIGEVTIGANVMVSPMASI
RSDEGMPIFVGDRSNVQDGVVLHALETINEEGEPIEDNIVEVDGKEYAVY
IGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGNNCVLEPRSAAIG
VTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVVYVNVHLAEG
YKETS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

3otz Chain A Residue 214 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3otz Crystal structure of gamma-carbonic anhydrase W19A mutant from Metanosarcina thermophila
Resolution	1.6 Å
Binding residue (original residue number in PDB)	H81 H122
Binding residue (residue number reindexed from 1)	H73 H114
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	E62 Q75 H81 E84 H117 H122 N202
Catalytic site (residue number reindexed from 1)	E54 Q67 H73 E76 H109 H114 N194
Enzyme Commision number	4.2.1.1: carbonic anhydrase.

Gene Ontology

	Molecular Function
GO:0004089	carbonate dehydratase activity
GO:0008270	zinc ion binding
GO:0016829	lyase activity
GO:0043199	sulfate binding
GO:0046872	metal ion binding
GO:0050897	cobalt ion binding
GO:0071890	bicarbonate binding

	Cellular Component
GO:0005576	extracellular region

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:3otz, PDBe:3otz, PDBj:3otz
PDBsum	3otz
PubMed
UniProt	P40881\|CAH_METTT Carbonic anhydrase (Gene Name=MSTHT_0588)

[Back to BioLiP]