Structure of PDB 3osl Chain A Binding Site BS01

Receptor Information

>3osl Chain A (length=296) Species: 9913 (Bos taurus)

SYYEQYHSLNEIYSWIEVMTERYPDMVEKIHIGSSYEKYPLYVLKVSKKN
AMWIDCGIHAREWISPAFCLWFVGSVTYYYGKNLLKHMDFYIMPVVNVDG
YDYTWKKDRMWRKNRSLHEKNACVGTDLNRNFASKHWCGEGASSSSCSEI
YCGTYPESEPEVKAVADFLRRNIKHIKAYISMHSYSQKIVFPYSYSRSRS
KDHEELSLVAREAVFAMENIHRNIRYTHGSGSESLYLAPGGSDDWIYDLG
IKYSFTFELRDKGKYGFLLPESYIRPTCSEALVAVAKIASHVVKNV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3osl Chain A Residue 999

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3osl Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates.
• Resolution: 6.0 Å
• Binding residue (original residue number in PDB): H181 E184 H310
• Binding residue (residue number reindexed from 1): H59 E62 H183
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H181 E184 R239 H310 E385
• Catalytic site (residue number reindexed from 1): H59 E62 R112 H183 E258
• Enzyme Commision number: 3.4.17.20: carboxypeptidase U.

Gene Ontology

Molecular Function

• GO:0004180 carboxypeptidase activity
• GO:0004181 metallocarboxypeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation
• GO:0042730 fibrinolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:3osl, PDBe:3osl, PDBj:3osl
• PDBsum: 3osl
• PubMed: 20880845
• UniProt: Q2KIG3|CBPB2_BOVIN Carboxypeptidase B2 (Gene Name=CPB2)