Structure of PDB 3os2 Chain A Binding Site BS01

Receptor Information
>3os2 Chain A (length=365) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3os2 The mechanism of retroviral integration from X-ray structures of its key intermediates
Resolution3.32 Å
Binding residue
(original residue number in PDB)		I112 L113 R114 P115 E207 F208 S209 T210 Q215 S216 G218 R222 D226 R229 S258 P259 K345 N348 R350 T351
Binding residue
(residue number reindexed from 1)		I103 L104 R105 P106 E198 F199 S200 T201 Q206 S207 G209 R213 D217 R220 S249 P250 K336 N339 R341 T342
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3os2, PDBe:3os2, PDBj:3os2
PDBsum3os2
PubMed21068843
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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