Structure of PDB 3os0 Chain A Binding Site BS01
Receptor Information
>3os0 Chain A (length=365) Species:
11963
(Human spumaretrovirus) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH
Ligand information
>3os0 Chain C (length=19) [
Search DNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
attgtcatggaatttcgca
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
3os0
The mechanism of retroviral integration from X-ray structures of its key intermediates
Resolution
2.81 Å
Binding residue
(original residue number in PDB)
I112 L113 R114 P115 E207 F208 S209 T210 Q215 S216 G218 K219 R222 R229 S258 P259 L347 N348 R350 T351
Binding residue
(residue number reindexed from 1)
I103 L104 R105 P106 E198 F199 S200 T201 Q206 S207 G209 K210 R213 R220 S249 P250 L338 N339 R341 T342
Enzymatic activity
Enzyme Commision number
2.7.7.-
2.7.7.49
: RNA-directed DNA polymerase.
2.7.7.7
: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4
: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
Biological Process
GO:0015074
DNA integration
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:3os0
,
PDBe:3os0
,
PDBj:3os0
PDBsum
3os0
PubMed
21068843
UniProt
P14350
|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)
[
Back to BioLiP
]