Structure of PDB 3omf Chain A Binding Site BS01

Receptor Information
>3omf Chain A (length=111) Species: 294381 (Entamoeba histolytica HM-1:IMSS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSCIFCKIAQKQIPSTIVYEDDEIFAFKDINPIAPIHILVIPKQHIASLN
EITEENEAFIGKVLYKVSLIGKKECPEGYRVVNNIGEDAGQTVKHIHFHI
LGGKKLAWDKL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3omf Chain A Residue 114 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3omf Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C5 C8 H47 H97
Binding residue
(residue number reindexed from 1)		C3 C6 H45 H95
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N86 H97 H99 H101
Catalytic site (residue number reindexed from 1) N84 H95 H97 H99
Enzyme Commision number 3.9.1.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0043530 adenosine 5'-monophosphoramidase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3omf, PDBe:3omf, PDBj:3omf
PDBsum3omf
PubMed25945711
UniProtC4LYI2|HIT_ENTH1 Histidine triad nucleotide-binding protein (Gene Name=EHI_093910)

[Back to BioLiP]