Structure of PDB 3ol8 Chain A Binding Site BS01

Receptor Information
>3ol8 Chain A (length=461) Species: 12080 (Poliovirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRL
KTDFEEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQMCLEDA
MYGTDGLEALDLSTSAGYPYVAMGKKKRDILNKQTRDTKEMQKLLDTYGI
NLPLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMRMAFGNLYAAFHK
NPGVITGSAVGCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFEALK
MVLEKIGFGDRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTSIFNSMI
NNLIIRTLLLKTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQSGKDY
GLTMTPADKSATFETVTWENVTFLKRFFRADEKYPFLIHPVMPMKEIHES
IRWTKDPRNTQDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIGRALDLPEY
STLYRRWLDSF
Ligand information
Receptor-Ligand Complex Structure
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PDB3ol8 Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		A19 P20 E108 T114 S115 K127 Y157 K159 I176 E177 A178 R188 H199 V210 G211 C212 D213 G289 C290 Y326 R415 L419
Binding residue
(residue number reindexed from 1)		A19 P20 E108 T114 S115 K127 Y157 K159 I176 E177 A178 R188 H199 V210 G211 C212 D213 G289 C290 Y326 R415 L419
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3ol8, PDBe:3ol8, PDBj:3ol8
PDBsum3ol8
PubMed21148772
UniProtB3VQP5

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