Structure of PDB 3ojy Chain A Binding Site BS01

Receptor Information
>3ojy Chain A (length=478) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQ
ASCSSSTTCQAQCGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDV
RAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETVYNG
EWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNA
NDLLSKVKSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGML
QSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESL
GITSRDITTCFGGSLGIQYHCKKFGGGKTERARKAMAVEDIISRVRGGSR
STITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALD
QYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEAKADGSWSC
WSSWSVCRAGIQERRRECSCPGRKVQTQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3ojy Chain A Residue 555 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ojy Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		L83 N86 D88 D90 D96 E97
Binding residue
(residue number reindexed from 1)		L80 N83 D85 D87 D93 E94
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001848 complement binding
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ojy, PDBe:3ojy, PDBj:3ojy
PDBsum3ojy
PubMed21454577
UniProtP07357|CO8A_HUMAN Complement component C8 alpha chain (Gene Name=C8A)

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