Structure of PDB 3o8c Chain A Binding Site BS01

Receptor Information

>3o8c Chain A (length=645) Species: 31647 (Hepatitis C virus subtype 1b)

GSVVIVGRIILSGSGSITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVV
STATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQ
APPGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLK
GSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRSPVFTD
NSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATL
GFGAYMSKAHGIDPNIRTGVRTITTGAPVTYSTYGKFLADGGCSGGAYDI
IICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNI
EEVALSNTGEIPFYGKAIPIEAIRGGRHLIFCHSKKKCDELAAKLSGLGI
NAVAYYRGLDVSVIPTIGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTV
DFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRRGIYRFVTPGERPSGMF
DSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVF
TGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLI
RLKPTLHGPTPLLYRLGAVQNEVTLTHPITKYIMACMSADLEVVT

Ligand information

>3o8c Chain C (length=6)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 3o8c Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): S231 V232 T254 G255 T269 G271 K272 A275 H369 S370 K371 R393 T411 A413 V432 W501 Y502 K551 N556
• Binding residue (residue number reindexed from 1): S245 V246 T268 G269 T283 G285 K286 A289 H383 S384 K385 R407 T425 A427 V446 W515 Y516 K565 N570

Enzymatic activity

• Catalytic site (original residue number in PDB): T10 C16 H57 D81 G137 S139
• Catalytic site (residue number reindexed from 1): T24 C30 H71 D95 G151 S153
• Enzyme Commision number: 3.4.21.98: hepacivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019087 transformation of host cell by virus

External links

• PDB: RCSB:3o8c, PDBe:3o8c, PDBj:3o8c
• PDBsum: 3o8c
• PubMed: 21145896
• UniProt: Q99AU2