Structure of PDB 3o4n Chain A Binding Site BS01

Receptor Information
>3o4n Chain A (length=133) Species: 11886 (Rous sarcoma virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVAAQHHWATA
IAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTQAMVERANRLLKDK
IRVLAEGDGFMKRIPASKQGELLAKAMYALNHF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3o4n Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3o4n A crystal structure of the catalytic core domain of an avian sarcoma and leukemia virus integrase suggests an alternate dimeric assembly.
Resolution1.8 Å
Binding residue
(original residue number in PDB)
D64 D121
Binding residue
(residue number reindexed from 1)
D6 D63
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function

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Biological Process
External links
PDB RCSB:3o4n, PDBe:3o4n, PDBj:3o4n
PDBsum3o4n
PubMed21857987
UniProtO92956|POL_RSVSB Gag-Pol polyprotein (Gene Name=gag-pol)

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