Structure of PDB 3o37 Chain A Binding Site BS01
Receptor Information
>3o37 Chain A (length=175) Species:
9606
(Homo sapiens) [
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NEDWCAVCQNGGELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLS
KPEVEYDCEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLT
VPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNE
PDSEVANAGIKLENYFEELLKNLYP
Ligand information
>3o37 Chain E (length=10) Species:
9606
(Homo sapiens) [
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ARTKQTARKS
Receptor-Ligand Complex Structure
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PDB
3o37
TRIM24 links a non-canonical histone signature to breast cancer.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
N825 E826 D827 W828 Q833 N834 G835 G836 E837 L838 C840 C841 E842 F860 P861 G863
Binding residue
(residue number reindexed from 1)
N1 E2 D3 W4 Q9 N10 G11 G12 E13 L14 C16 C17 E18 F36 P37 G39
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:3o37
,
PDBe:3o37
,
PDBj:3o37
PDBsum
3o37
PubMed
21164480
UniProt
O15164
|TIF1A_HUMAN Transcription intermediary factor 1-alpha (Gene Name=TRIM24)
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