Structure of PDB 3o05 Chain A Binding Site BS01

Receptor Information
>3o05 Chain A (length=261) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLKGGVIMDVVTPEQAKIAEKSGACAVMALESIPADMRKSGKVCRMSDPK
MIKDIMNSVSIPVMAKVRIGHFVEAQIIEALEVDYIDESEVLTPADWTHH
IEKDKFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHIR
RITEEIKACQQLKSEDDIAKVAEEMRVPVSLLKDVLEKGKLPVVNFAAGG
VATPADAALLMQLGCDGVFVGSGIFKSSNPVRLATAVVEATTHFDNPSKL
LEVSSDLGELM
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain3o05 Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3o05 Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1
Resolution2.2 Å
Binding residue
(original residue number in PDB)		W111 R136 R137 K148
Binding residue
(residue number reindexed from 1)		W97 R122 R123 K134
Annotation score3
Enzymatic activity
Enzyme Commision number 4.3.3.6: pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0016843 amine-lyase activity
GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006543 glutamine catabolic process
GO:0008615 pyridoxine biosynthetic process
GO:0042819 vitamin B6 biosynthetic process
GO:0042823 pyridoxal phosphate biosynthetic process
GO:1901617 organic hydroxy compound biosynthetic process
Cellular Component
GO:1903600 glutaminase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3o05, PDBe:3o05, PDBj:3o05
PDBsum3o05
PubMed20919991
UniProtQ03148|SNZ1_YEAST Pyridoxal 5'-phosphate synthase subunit SNZ1 (Gene Name=SNZ1)

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