Structure of PDB 3nmx Chain A Binding Site BS01

Receptor Information
>3nmx Chain A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHNPMPAPVEHQICPAVCVLMKLSFDE
EHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTF
GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSK
KTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVD
GALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNL
IHSKHKMIAMGSAAALRNLMANRPAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3nmx Structural basis for the recognition of Asef by adenomatous polyposis coli.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		F458 M503 T506 N507 F510 G511 K516 Q542 S546 R549 N550 W553 W593 N594
Binding residue
(residue number reindexed from 1)		F48 M93 T96 N97 F100 G101 K106 Q132 S136 R139 N140 W143 W183 N184
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nmx, PDBe:3nmx, PDBj:3nmx
PDBsum3nmx
PubMed21788986
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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