Structure of PDB 3ngo Chain A Binding Site BS01

Receptor Information
>3ngo Chain A (length=337) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPPRPWITLKERDILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEY
RKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRA
KIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNR
VMTKDNIGVAVVLEVHKELFKQLLIVANAHMHWDPEYSDVKLIQTMMFVS
EVKNILEKASIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELYNEC
LMNFSRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGV
LGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3ngo Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y201 H360 W363 N412 F484
Binding residue
(residue number reindexed from 1)		Y32 H180 W183 N220 F281
Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004535 poly(A)-specific ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3ngo, PDBe:3ngo, PDBj:3ngo
PDBsum3ngo
PubMed20628353
UniProtQ96LI5|CNO6L_HUMAN CCR4-NOT transcription complex subunit 6-like (Gene Name=CNOT6L)

[Back to BioLiP]