Structure of PDB 3ngd Chain A Binding Site BS01

Receptor Information
>3ngd Chain A (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSSGRESRQCPIPSHVIQKDVMTPMVD
ILMKLFRNMTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3ngd Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA Polymerase {iota}.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		L123 E127 K207 G241 G243 K245 T246 E358 S359 R360 Q361
Binding residue
(residue number reindexed from 1)		L98 E102 K182 G216 G218 K220 T221 E329 S330 R331 Q332
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3ngd, PDBe:3ngd, PDBj:3ngd
PDBsum3ngd
PubMed20961860
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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