Structure of PDB 3nfz Chain A Binding Site BS01

Receptor Information
>3nfz Chain A (length=305) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SREPLLRVAVTGGTHGNEMCGVYLARYWLQNPGELQRPSFSAMPVLANPA
ATAACCRYLDRDLNRSCTLTFLGSTATPDDPYEVKRARELNQLLGPKGTG
QAFDFTLDLHNTTANTGVCLISESNISFNLHLCHYLQRQNPGMPCRLFLY
EPAGTETFSVESISKNGICLAMGPQPQGVLRADLFSRMRALVASILDFIE
LFNQGMDLPAFEMDIYRNLGSVDFPRTADGDLAGTVHPQLQDHDFEPLRP
GEPIFKLFSGEDVLYEGDSIVYPVFINEAAYYEKHVAFLKSEKIRVTVPA
LLRLT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3nfz Chain A Residue 319 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3nfz Structures of aminoacylase 3 in complex with acetylated substrates.
Resolution2.147 Å
Binding residue
(original residue number in PDB)		H21 E24 H116
Binding residue
(residue number reindexed from 1)		H15 E18 H110
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.114: N-acyl-aromatic-L-amino acid amidohydrolase.
Gene Ontology
Molecular Function
GO:0004046 aminoacylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:3nfz, PDBe:3nfz, PDBj:3nfz
PDBsum3nfz
PubMed20921362
UniProtQ91XE4|ACY3_MOUSE N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (Gene Name=Acy3)

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