Structure of PDB 3n96 Chain A Binding Site BS01

Receptor Information

>3n96 Chain A (length=473) Species: 9606,83333

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFAALLHSLLEANCSLALAEELLLDGWGPP
LDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAY
RECLENGTWASKINYSQCEPILD

Ligand information

>3n96 Chain G (length=14) Species: 9606 (Homo sapiens)

RERAEQNRIIFDSV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3n96 Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
• Resolution: 2.75 Å
• Binding residue (original residue number in PDB): D-329 K-328 K-324 D-163 Q46 I47 F68 V71 Y73 Y95 P100
• Binding residue (residue number reindexed from 1): D41 K42 K46 D207 Q416 I417 F438 V441 Y443 Y465 P470

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0015144 carbohydrate transmembrane transporter activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3n96, PDBe:3n96, PDBj:3n96
• PDBsum: 3n96
• UniProt: P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
  Q13324|CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (Gene Name=CRHR2)