Structure of PDB 3mxi Chain A Binding Site BS01

Receptor Information
>3mxi Chain A (length=219) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPHGHMQTLIFLNLEATGLPSSRPEVTELCLLAVHRRALESQGHPPPVP
RPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLAILL
RAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDSIAA
LKALEQASKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQWKPQALL
QWVDEHARPFSTVKPMYGT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mxi X-ray Crystal Structures of TREX1 3' Exonuclease Autoimmune Disease Mutants
Resolution2.55 Å
Binding residue
(original residue number in PDB)		E20 A21 L24 G80 I84 T85 H124 N125 R128 Y129 S176 S178 L179 H195
Binding residue
(residue number reindexed from 1)		E16 A17 L20 G72 I76 T77 H116 N117 R120 Y121 S160 S162 L163 H179
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3mxi, PDBe:3mxi, PDBj:3mxi
PDBsum3mxi
PubMed
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

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