Structure of PDB 3mwt Chain A Binding Site BS01

Receptor Information
>3mwt Chain A (length=513) Species: 11622 (Lassa virus Josiah) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IKSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRK
ERRDDNDLKRLRDLNQAVNNLVELKSTQQKSILRVGTLTSDDLLILAADL
EKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNMIGMDGVVRVWDVK
NAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLIYTAKYPNTS
DLDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLET
IKVSPQTMDGILKSILKVKKALGMFISDTPGERNPYENILYKICLSGDGW
PYIASRTSITGRAWENTVVDLGLTYSQLMTLKDAMLQLDPNAKTWMDIEG
RPEDPVEIALYQPSSGCYIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQ
PGLTSAVIDALPRNMVITCQGSDDIRKLLESQGRKDIKLIDIALSKTDSR
KYENAVWDQYKDLCHMHTGVVVEKKEEITPHCALMDCIMFDAAVSGGLTS
VLRAVLPRDMVFR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3mwt Chain A Residue 680 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mwt Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Resolution1.982 Å
Binding residue
(original residue number in PDB)		D389 E391 D533
Binding residue
(residue number reindexed from 1)		D347 E349 D486
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0019049 virus-mediated perturbation of host defense response
GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
GO:0039689 negative stranded viral RNA replication
GO:0039696 RNA-templated viral transcription
GO:0039724 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
Cellular Component
GO:0019013 viral nucleocapsid
GO:0019029 helical viral capsid
GO:0030430 host cell cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mwt, PDBe:3mwt, PDBj:3mwt
PDBsum3mwt
PubMed21085117
UniProtP13699|NCAP_LASSJ Nucleoprotein (Gene Name=N)

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