Structure of PDB 3mvh Chain A Binding Site BS01

Receptor Information
>3mvh Chain A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH
TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERV
FSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG
LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC
GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGG
GSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTA
QRPHFPQFDYSA
Ligand information
Receptor-Ligand Complex Structure
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PDB3mvh Design of selective, ATP-competitive inhibitors of Akt.
Resolution2.01 Å
Binding residue
(original residue number in PDB)		H194 E234 F236 D274 K276 E278 F309 C310 G311 T312 P313 E314 Y315 E341
Binding residue
(residue number reindexed from 1)		H50 E90 F92 D130 K132 E134 F165 C166 G167 T168 P169 E170 Y171 E197
Enzymatic activity
Catalytic site (original residue number in PDB) D274 K276 N279 D292 T312
Catalytic site (residue number reindexed from 1) D130 K132 N135 D148 T168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3mvh, PDBe:3mvh, PDBj:3mvh
PDBsum3mvh
PubMed20481595
UniProtP31749|AKT1_HUMAN RAC-alpha serine/threonine-protein kinase (Gene Name=AKT1)

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