Structure of PDB 3mr3 Chain A Binding Site BS01

Receptor Information
>3mr3 Chain A (length=428) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQPISADLLPSTYIEG
LPQGETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIK
NCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mr3 Structure and mechanism of human DNA polymerase eta.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 K86 R93 K293 K311 P316 K317 T318 G320 S322 K323 N324 P326 G327
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 K89 R96 K289 K307 P312 K313 T314 G316 S318 K319 N320 P322 G323
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mr3, PDBe:3mr3, PDBj:3mr3
PDBsum3mr3
PubMed20577208
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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