Structure of PDB 3mr2 Chain A Binding Site BS01

Receptor Information
>3mr2 Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEM
RAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQM
PIRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYA
MCRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEE
RLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAF
TVIKNCNTSGTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mr2 Structure and mechanism of human DNA polymerase eta.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 S62 K86 R93 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 S65 K89 R96 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 R351
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mr2, PDBe:3mr2, PDBj:3mr2
PDBsum3mr2
PubMed20577208
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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