Structure of PDB 3mn7 Chain A Binding Site BS01

Receptor Information
>3mn7 Chain A (length=359) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPDSYVGDEAQSKRGILT
LKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANR
EKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIY
EGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTEEREIVRDIKEKL
CYVALDFEQEMATAASSSSLEKSYELKDGQVITIGNERFRCPEALFQPSF
LGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKE
ITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESG
PSIVHRKCF
Ligand information
>3mn7 Chain S (length=20) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PSPREQLMESIRKGKELKQA
Receptor-Ligand Complex Structure
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PDB3mn7 Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		G23 D25 Y143 T148 E167 Y169 S348 T351
Binding residue
(residue number reindexed from 1)		G19 D21 Y127 T132 E151 Y153 S332 T335
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000281 mitotic cytokinesis
GO:0006338 chromatin remodeling
GO:0007291 sperm individualization
GO:0030723 ovarian fusome organization
GO:0032507 maintenance of protein location in cell
GO:0035148 tube formation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031011 Ino80 complex
GO:0035060 brahma complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mn7, PDBe:3mn7, PDBj:3mn7
PDBsum3mn7
PubMed20538977
UniProtP10987|ACT1_DROME Actin-5C (Gene Name=Act5C)

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