Structure of PDB 3mfk Chain A Binding Site BS01

Receptor Information
>3mfk Chain A (length=138) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQ
SFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNI
IHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDA
Ligand information
Receptor-Ligand Complex Structure
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PDB3mfk Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y386 R391 R394 Y397 K404 R409 Y410
Binding residue
(residue number reindexed from 1)		Y85 R90 R93 Y96 K103 R108 Y109
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:3mfk, PDBe:3mfk, PDBj:3mfk
PDBsum3mfk
PubMed20686355
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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