Structure of PDB 3mfh Chain A Binding Site BS01

Receptor Information
>3mfh Chain A (length=510) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKEDP
VVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKGED
FWQYHDGCGSWVPAKQISVEDHKVSLEPYRRESRKALAIFKWACDLVERA
SIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGNYDIN
SHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKGIRDSI
KDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCGKFEI
TSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDAKVKQ
SDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKNLR
GKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLKTKSY
EVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTKLSMT
ITNFDIIDLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3mfh Structural basis for the suppression of skin cancers by DNA polymerase eta.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E156 K272 W306 T307 G309 G310 V311 L312 R456 K457 S458 G459
Binding residue
(residue number reindexed from 1)		E154 K270 W304 T305 G307 G308 V309 L310 R454 K455 S456 G457
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3mfh, PDBe:3mfh, PDBj:3mfh
PDBsum3mfh
PubMed20577207
UniProtQ04049|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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