Structure of PDB 3m4z Chain A Binding Site BS01

Receptor Information
>3m4z Chain A (length=309) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLKDRYEAIG
GISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMH
KDGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEP
KFVTYWVDRVKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLH
ESAKLIAEGAGVSEYAVGWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAF
VYVPVGFVADHLEVLYDNDYECKVVTDDIGASYYRPEMPNAKPEFIDALA
TVVLKKLGR
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain3m4z Chain A Residue 310 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3m4z Bacterial ferrochelatase goes human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase
Resolution1.94 Å
Binding residue
(original residue number in PDB)		H182 E263
Binding residue
(residue number reindexed from 1)		H182 E263
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y12 I28 P34 K86 H87 H182 D260 E263 D267
Catalytic site (residue number reindexed from 1) Y12 I28 P34 K86 H87 H182 D260 E263 D267
Enzyme Commision number 4.99.1.9: coproporphyrin ferrochelatase.
Gene Ontology
Molecular Function
GO:0004325 ferrochelatase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006783 heme biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3m4z, PDBe:3m4z, PDBj:3m4z
PDBsum3m4z
PubMed
UniProtP32396|CPFC_BACSU Coproporphyrin III ferrochelatase (Gene Name=cpfC)

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