Structure of PDB 3m4w Chain A Binding Site BS01

Receptor Information

>3m4w Chain A (length=284) Species: 83333 (Escherichia coli K-12)

PASGALLQQMNLASQSLNYELSFISINKQGVESLRYRHARLDNRPLAQLL
QMDGPRREVVQRGNEISYFEPGLEPFTLNGDYIVDSLPSLIYTDFKRLSP
YYDFISVGRTRIADRLCEVIRVVARDGTRYSYIVWMDTESKLPMRVDLLD
RDGETLEQFRVIAFNVNQDISSSMQTLAKANLPPLLSVPVGEKAKFSWTP
TWLPQGFSEVSSSRRMPIESRLYSDGLFSFSVNVNRATPSSTDQMLRTGR
RTVSTSVRDNAEITIVGELPPQTAKRIAENIKFG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3m4w Chain A Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3m4w Structural basis for the negative regulation of bacterial stress response by RseB
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): D174 D176
• Binding residue (residue number reindexed from 1): D150 D152
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008289 lipid binding
• GO:0042802 identical protein binding
• GO:0045152 antisigma factor binding

Biological Process

• GO:0032885 regulation of polysaccharide biosynthetic process
• GO:0045892 negative regulation of DNA-templated transcription
• GO:0050821 protein stabilization

Cellular Component

• GO:0005886 plasma membrane
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:1903865 sigma factor antagonist complex

External links

• PDB: RCSB:3m4w, PDBe:3m4w, PDBj:3m4w
• PDBsum: 3m4w
• PubMed: 20512978
• UniProt: P0AFX9|RSEB_ECOLI Sigma-E factor regulatory protein RseB (Gene Name=rseB)