Structure of PDB 3m4a Chain A Binding Site BS01

Receptor Information
>3m4a Chain A (length=304) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSRTELLARRARIARLAVPPAYQDVYVSPDAENELQAFGRDAARLQYRYH
PDFVALKKWQRLTRFAGALPTLKVATTADLRASGLPPRKVMALMTRLLHV
ARFRVGSDIYARQHKTYGLSTLRQRHVVVDGNTVTFRFKGKHGVSQHKAT
SDRTLAANMQKLLDLPGPWLFQTVDAGGERRRIHSTELNAYLREVIGPFT
AKDFRTWGGTLLAAEYLAQQGTESSERQAKKVLVDCVKFVADDLGNTPAV
TRGSYICPVIFDRYLDGKVLDDYEPRTERQEAELEGLTRSEGALKRMLES
ERTL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3m4a Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		T110 L113 R114 S116 K122 R129 R186 T187 N191
Binding residue
(residue number reindexed from 1)		T77 L80 R81 S83 K89 R96 R153 T154 N158
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3m4a, PDBe:3m4a, PDBj:3m4a
PDBsum3m4a
PubMed20541510
UniProtQ9RWH8

[Back to BioLiP]