Structure of PDB 3m1c Chain A Binding Site BS01

Receptor Information
>3m1c Chain A (length=719) Species: 10315 (Human herpesvirus 2 strain HG52) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLWLPNTPDASDPQRGRLAPPGELNLTTASVPMLRWYAERFCFVLVTTAE
FPRDPGQLLYIPKTYLLAEVTQLKGLSHNPGASALLRSRAWVTFAAAPDR
EGLTFPRGDDGATERHPDGRRNAPPPGPPAGTPRHPTTNLSIAHLHNASV
TWLAARGLLRTPGRYVYLSPSASTWPVGVWTTGGLAFGCDAALVRARYGK
GFMGLVISMRDSPPAEIIVVPADKTLARVGNPTDENAPAVLPGPPAGPRY
RVFVLGAPNGSALDALRRVAGYPEESTNYAQYMSRAYAEFLGEDPGSGTD
ARPSLFWRLAGLLASSGFAFVNAAHAHDAIRLSDLLGFLAHSRVLAGLAA
RGAAGCAADSVFLNVSVLDPAARLRLEARLGHLVAAILEREQSLVAHALG
YQLAFVLDSPAAYGAVAPSAARLIDALYAEFLGGRALTAPMVRRALFYAT
AVLRAPFLAGAPSAEQRERARRGLLITTALCTSDVAAATHADLRAALART
DHQKNLFWLPDHFSPCAASLRFDLAEGGFILDALAMATRSDIPADVMAQQ
TRGVASVLTRWAHYNALIRAFVPEATHQCSGPSHNAEPRILVPITHNASY
VVTHTPLPRGIGYKLTGVDVRRPLFITYLTATCEGHAREIEPKRLVRDLG
LVGAVFLRYTPAGEVMSVLLVDTDATQQQLAQGPVAGTPNVFSSDVPSVA
LLLFPNGTVIHLLAFDTLP
Ligand information
Ligand IDXYL
InChIInChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+
InChIKeyHEBKCHPVOIAQTA-SCDXWVJYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C([C@@H](C([C@@H](CO)O)O)O)O
OpenEye OEToolkits 1.5.0C(C(C(C(CO)O)O)O)O
CACTVS 3.341OC[CH](O)[CH](O)[CH](O)CO
CACTVS 3.341OC[C@H](O)[C@@H](O)[C@H](O)CO
ACDLabs 10.04OC(CO)C(O)C(O)CO
FormulaC5 H12 O5
NameXylitol;
D-Xylitol
ChEMBLCHEMBL96783
DrugBankDB11195
ZINCZINC000100018612
PDB chain3m1c Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3m1c Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N658 A659 R682
Binding residue
(residue number reindexed from 1)		N585 A586 R609
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3m1c, PDBe:3m1c, PDBj:3m1c
PDBsum3m1c
PubMed20601960
UniProtP89445|GH_HHV2H Envelope glycoprotein H (Gene Name=gH)

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