Structure of PDB 3lyo Chain A Binding Site BS01

Receptor Information

>3lyo Chain A (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Ligand information

• Ligand ID: CCN
• InChI: InChI=1S/C2H3N/c1-2-3/h1H3
• InChIKey: WEVYAHXRMPXWCK-UHFFFAOYSA-N
• SMILES:
  ACDLabs 11.02: N#CC
  CACTVS 3.352
  OpenEye OEToolkits 1.7.0: CC#N
• Formula: C2 H3 N
• Name: ACETONITRILE
• ChEMBL: CHEMBL45211
• PDB chain: 3lyo Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3lyo X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture.
• Resolution: 1.93 Å
• Binding residue (original residue number in PDB): I58 N59 A107 W108
• Binding residue (residue number reindexed from 1): I58 N59 A107 W108
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:3lyo, PDBe:3lyo, PDBj:3lyo
• PDBsum: 3lyo
• PubMed: 9659395
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)