Structure of PDB 3lw6 Chain A Binding Site BS01

Receptor Information
>3lw6 Chain A (length=241) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GASVHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRFR
FNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIAG
PKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLEDDEFFVRIRD
AGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKTG
LDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain3lw6 Chain A Residue 312 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3lw6 Crystal structure of the catalytic domain of Drosophila beta1,4-Galactosyltransferase-7.
Resolution1.81 Å
Binding residue
(original residue number in PDB)		P82 F83 R84 R86 F121 D145 V146 D147 Y177 H241 H243 R250
Binding residue
(residue number reindexed from 1)		P12 F13 R14 R16 F51 D75 V76 D77 Y107 H171 H173 R180
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) D145 D147 W207 E210 D211 T238 H241 H243
Catalytic site (residue number reindexed from 1) D75 D77 W137 E140 D141 T168 H171 H173
Enzyme Commision number 2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3lw6, PDBe:3lw6, PDBj:3lw6
PDBsum3lw6
PubMed20236943
UniProtQ9VBZ9|B4GT7_DROME Beta-1,4-galactosyltransferase 7 (Gene Name=beta4GalT7)

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