Structure of PDB 3lrn Chain A Binding Site BS01
Receptor Information
>3lrn Chain A (length=121) Species:
9606
(Homo sapiens) [
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KENKKLLCRKCKALACYTADVRVIEESHYTVLGDAFKECFVSRPHPKPKQ
FSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQ
TLYSKWKDFHFEKIPFDPAEM
Ligand information
>3lrn Chain C (length=14) [
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ggcgcgcgcgcgcc
..............
Receptor-Ligand Complex Structure
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PDB
3lrn
The Structural Basis of 5' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
S829 H830 H847 F853 K858 K861 I875 K888 W908
Binding residue
(residue number reindexed from 1)
S27 H28 H45 F51 K56 K59 I73 K86 W106
Binding affinity
PDBbind-CN
: Kd=0.32nM
Enzymatic activity
Enzyme Commision number
3.6.4.13
: RNA helicase.
External links
PDB
RCSB:3lrn
,
PDBe:3lrn
,
PDBj:3lrn
PDBsum
3lrn
PubMed
20637642
UniProt
O95786
|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)
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