Structure of PDB 3lku Chain A Binding Site BS01

Receptor Information
>3lku Chain A (length=286) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKTLQRFENKIKAGDYYEAHQTLRTIANRYVRSKSYEHAIELISQGALSF
LKAKQGGSGTDLIFYLLEVYDLAEVKVDDISVARLVRLIAELDPSEPNLK
DVITGMNNWSIKFSEYKFGDPYLHNTIGSKLLEGDFVYEAERYFMLGTHD
SMIKYVDLLWDWLCQVDDIEDSTVAEFFSRLVFNYLFISNISFAHESKDI
FLERFIEKFHPKYEKIDKNGYEIVFFEDYSDLNFLQLLLITCQTKDKSYF
LNLKNHYLDFSQAYKSELEFLGQEYFNIVAPKQTNF
Ligand information
Ligand IDPRO
InChIInChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKeyONIBWKKTOPOVIA-BYPYZUCNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C[C@H](NC1)C(=O)O
CACTVS 3.341OC(=O)[C@@H]1CCCN1
CACTVS 3.341OC(=O)[CH]1CCCN1
OpenEye OEToolkits 1.5.0C1CC(NC1)C(=O)O
ACDLabs 10.04O=C(O)C1NCCC1
FormulaC5 H9 N O2
NamePROLINE
ChEMBLCHEMBL54922
DrugBankDB00172
ZINCZINC000000895360
PDB chain3lku Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3lku Structural characterization of the Get4/Get5 complex and its interaction with Get3.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		S48 Y49 E50 H51
Binding residue
(residue number reindexed from 1)		S35 Y36 E37 H38
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
GO:0016192 vesicle-mediated transport
GO:0045048 protein insertion into ER membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0072380 TRC complex

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:3lku, PDBe:3lku, PDBj:3lku
PDBsum3lku
PubMed20554915
UniProtQ12125|GET4_YEAST Golgi to ER traffic protein 4 (Gene Name=GET4)

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