Structure of PDB 3l9q Chain A Binding Site BS01

Receptor Information
>3l9q Chain A (length=171) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSSLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLT
LEQALQFWKQFDKGYSYNIRHSFTDYTPFSCLKIILSNPPSQGDYHGCPF
RHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKYFEMIHNVDD
CGFSLNHPNQFFCESQRILNG
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain3l9q Chain A Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3l9q Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.
Resolution1.698 Å
Binding residue
(original residue number in PDB)		P285 C287 C367 I370 C384 F386 Q421 C424 L441 P444
Binding residue
(residue number reindexed from 1)		P16 C18 C81 I84 C98 F100 Q135 C138 L155 P158
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:3l9q, PDBe:3l9q, PDBj:3l9q
PDBsum3l9q
PubMed20643958
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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