Structure of PDB 3l6x Chain A Binding Site BS01

Receptor Information
>3l6x Chain A (length=434) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKL
KGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALV
RLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSG
WEHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIG
QKDSDSKLVENCVCLLRNLSYQVHREIPQAERSPARGYELLFQPEVVRIY
ISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADL
LTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSW
NFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKE
VRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3l6x Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		N362 W363 M374 N385 A386 A388 Y389 Q391 H392 Y395 R396 K401 K433 N434 F437 G438 K444 G474 W477 N478 S481 K486 N536 K574
Binding residue
(residue number reindexed from 1)		N5 W6 M17 N28 A29 A31 Y32 Q34 H35 Y38 R39 K44 K76 N77 F80 G81 K87 G117 W120 N121 S124 K129 N169 K207
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0098609 cell-cell adhesion

View graph for
Biological Process
External links
PDB RCSB:3l6x, PDBe:3l6x, PDBj:3l6x
PDBsum3l6x
PubMed20371349
UniProtO60716|CTND1_HUMAN Catenin delta-1 (Gene Name=CTNND1)

[Back to BioLiP]