Structure of PDB 3l3q Chain A Binding Site BS01
Receptor Information
>3l3q Chain A (length=427) Species:
10090
(Mus musculus) [
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QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS
Ligand information
>3l3q Chain B (length=9) [
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PFKKKRREA
Receptor-Ligand Complex Structure
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PDB
3l3q
Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
L104 S105 E107 P110 F138 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 Y277
Binding residue
(residue number reindexed from 1)
L34 S35 E37 P40 F68 W72 N76 S79 G80 T85 Q111 W114 N118 G121 D122 W161 R168 W203 Y207
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3l3q
,
PDBe:3l3q
,
PDBj:3l3q
PDBsum
3l3q
PubMed
20406804
UniProt
P52293
|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)
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