Structure of PDB 3l2w Chain A Binding Site BS01

Receptor Information

>3l2w Chain A (length=365) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIVL
QAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKAS
GPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPTK
APSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEFS
TPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYSP
VLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTPP
ASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHLG
NNRTVSIDNLKPTSH

Ligand information

>3l2w Chain C (length=19) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

attgtcatggaattttgta

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3l2w Retroviral intasome assembly and inhibition of DNA strand transfer
Resolution	3.2 Å
Binding residue (original residue number in PDB)	I112 L113 R114 P115 E207 F208 S209 T210 Q215 S216 G218 K219 R222 R229 S258 P259 L347 R350 T351 T363
Binding residue (residue number reindexed from 1)	I103 L104 R105 P106 E198 F199 S200 T201 Q206 S207 G209 K210 R213 R220 S249 P250 L338 R341 T342 T354

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding

	Biological Process
GO:0015074	DNA integration

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Molecular Function

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Biological Process

External links

PDB	RCSB:3l2w, PDBe:3l2w, PDBj:3l2w
PDBsum	3l2w
PubMed	20118915
UniProt	P14350\|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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