Structure of PDB 3l2p Chain A Binding Site BS01

Receptor Information
>3l2p Chain A (length=535) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGGDVYLTVKLLL
PGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQS
KSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKC
IIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEV
ELSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKN
GDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTG
KPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHD
NMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPG
KRHWLKVKKDYLNMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQK
WCTVTKCAGGHDDATLARLQNELDMVKISKAAVWEITGAEFSKSEAHTAD
GISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3l2p Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		V231 N233 N235 K237 Q238 G424 E425 S440 S442 K444 F487
Binding residue
(residue number reindexed from 1)		V57 N59 N61 K63 Q64 G242 E243 S258 S260 K262 F305
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3l2p, PDBe:3l2p, PDBj:3l2p
PDBsum3l2p
PubMed20518483
UniProtP49916|DNLI3_HUMAN DNA ligase 3 (Gene Name=LIG3)

[Back to BioLiP]